Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
Zeashan Hussain
Department of Chemistry, Mahatma Gandhi Institute of Pharmacy, Lucknow, Uttar Pradesh, India-227101, IndiaPublications
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Review Article
1, 5-Benzothiazepine: As Potential Biologically Active Agent
Author(s): Vikash Kumar Chaudhri*, Devender Pathak and Zeashan Hussain
The 1,5-benzothiazepine ring system is an important pharmacophore in medicinal chemistry and modern drug discovery. 1,5-benzothiazepine and its derivatives are used in organic synthesis and they are used in evaluating new product that possesses different biological activities. The first molecule of 1,5-benzothiazepine used clinically was diltiazem, followed by clentiazem, for their cardiovascular action. Some of the 1,5-benzothiazepine derivatives were also used clinically for CNS disorders which includes thiazesim, clothiapine and quetiapine. Therefore, the 1,5-benzothiazepines are useful compounds in the drug research which has stimulated the invention of a wide range of synthetic methods for their preparation and chemical transformations. This review article covers the most active 1,5-benzothiazepine derivatives and discusses the structure-activity relationship of the most pote.. Read More»
DOI: 10.4172/0975-413X.14.10.19-33
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Citations : 15261
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