Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
Wanche EM
Department of Pharmacology & Toxicology, Faculty of Pharmaceutical Sciences, University of Jos, Jos, NigeriaPublications
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Research
Protective Effect of Brassica olearacea Var. Capitata Extract on Glutathione-s-transferase, Catalase and Total Protein Activity in Dolutegravir-induced Toxicity
Author(s): Amagon L*, Falang KD, Bukar BB, Wanche EM and Amagon KI
Introduction: Oxidative stress is one of the leading causes of liver injury; the process of such damage involves the molecular reactions of highly reactive oxygen species that can lead to impaired liver functions. Objective: This study investigated the protective effect of Brassica oleracea (Red Cabbage against Dolutegravir-induced oxidative stress and assessed the safety of the plant extract in Drosophila melanogaster. Methods: In the first phase, there were three groups of flies in replicates of five (5), with each vial contained 50 flies of both gender; group one was the control, and the other flies were administered the toxicant for ten days, then homogenized, and the biochemical assays performed. In the second phase, there were five groups of flies in replicates of five (5), each vial contain.. Read More»
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Citations : 15261
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