Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
Vijayalakshmi R
Department of Pharmaceutical Analysis, GIET School of Pharmacy, NH-16 Chaitanya Knowledge City, Rajahmundry-533296, IndiaPublications
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Research Article
Chemometric-Assisted UV method for quantisation of Perindopril and Losartan in tablet dosage form
Author(s): Vijayalakshmi R*, Sundar VD and Dhanaraju MD
In very recent days multivariate calibration techniques are used to resolve mixtures of double or triple compounds with similar spectral characteristics. In many cases, these multivariate methods for the study of spectral data have many more benefits like simple processing and cheaper analysis. These methods have been very often applied for quantitation of drugs, as HPLC methods are tedious and conventional spectroscopic methods were slow, expensive and complex. The work proposal describes new spectrophotometric methods for the concurrent estimation of Perindopril (PRN) and Losartan (LRN) in their mixtures and dosage form. The stated chemometric methods are multivariate techniques including PCR and PLS. These techniques employ the concentration statistics matrix, produced by using the several combinations containing the two drugs dissolved in methanol. The absorbance input matrix rela.. Read More»
DOI: 10.4172/0975-413X.14.12.11-17
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