Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
Utkarsh Shashtri
Department of Pharmaceutics, KLE College of Pharmacy Belagavi, KLE Academy of Higher Education and Research, Belagavi-560010, Karnataka, IndiaPublications
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Research Article
RP-HPLC Method Development and Validation for Pioglitazone in Bulk and Marketed Formulation
Author(s): Meenaxi M. Maste*, Nikhil S. Gawas, Utkarsh Shashtri and Poonam Shelar
The work describes a precise, accurate and reproducible Reverse Phase High Performance Liquid Chromatographic (RP-HPLC) method for development and validation of Pioglitazone in tablet dosage form on Lachrome Liquid chromatographic system having PDA-20 A UV/VIS Detector using stationary phase C18 column (300 mm × 3.9 mm, 5 μm, particle size) and acetonitrile:phosphate buffer, (50:50 v/v) as mobile phase at flow rate of 1.00 ml/min and the detection wavelength was 267 nm. The retention time for Pioglitazone was found to be 8.08 min. The method was validated for precision, accuracy, linearity range, robustness, system stability, as per ICH guidelines Q2(R1)... Read More»
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