Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
Tesfaye Lamma
Department of Chemistry, College of Natural and Computational Sciences, Hawassa University, P.O. Box 05, Hawassa, EthiopiaPublications
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Research Article
Synthesis, Charactrization and Antibacterial Activity of Schiff Bases Derived from Phenyl Hydrazine Derivatives and their Cu (II) and Zn (II) Complexes
Author(s): Tesfaye Lamma, Adelew Filkale, Dagne Addisu Kure and Henok Brehanu Abebe*
Phenyl hydrazine schiff bases have received a lot of attention recently because of their biological importance and potential medical applications. These compounds are of particular interest because they have a variety of beneficial properties, including antibacterial, anticancer, antimalarial, antiinflammatory, antinociceptive, antitubercular, anthelmintic, antidiabetic and antiepileptic. In this research, phenyl hydrazine derivatives of Schiff base ligands namely ((E)-2-benzylidene-1-phenylhydrazine, (E)-2-(4-nitrobenzylidene) phenyl hydrazine, 2,2'-((1E, 1‘E)-hydrazine-1,2-diylidenebis (methanylylidene)) diphenol and (E)-2-(2-hydroxybenzylidene)-1-phenylhydrazine) and their copper(II) and zinc(II) complexes were synthesized and described. The synthesized ligands, were characterized by varieties of techniques including Fourier transform Infrared, UV-Visible and NMR (13.. Read More»
DOI: 10.4172/0975- 413X.16.4.375-394
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