Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
Swati R Dhande
Department of Pharmacology, Bharati Vidyapeeth College of Pharmacy, Navi Mumbai, IndiaPublications
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Research Article
To Evaluate the Interaction of Zandopa® Powder and Parkitidin Tablet in Haloperidol Induced Catalepsy Model in Rat
Author(s): Ravi A Vyas and Swati R Dhande*
Herb Drug Interaction (HDIs) is defined as an interaction between herbal medicinal products and allopathic drugs when administered concomitantly. HDIs alter the body’s function pharmacodynamically and pharmacokinetically. The study concerned on herb drug interaction of Zandopa® powder (Mucuna pruriens) and parkitidin tablet (Amantadine Hydrochloride) in haloperidol-induced catalepsy model in rats. The rats were divided into 5 groups namely group I vehicle control (1% Carboxy Methyl Cellulose (CMC)), group II disease control (1% Carboxy Methyl Cellulose (CMC), group III Zandopa® powder (775 mg/kg of body weight), group IV Parkitidin tablet (10 mg/kg of body weight) and group V combination (Zandopa® powder 775 mg/kg and Parkitidin tablet 10 mg/kg of body weight). Behavioral parameters i.e., muscle rigidity and locomotor activity and biochemic.. Read More»
DOI: 10.4172/0975-413X.16.1.166-171
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Citations : 15261
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