Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
Simanchal Dash
Department of Chemistry, Roland Institute of Technology, Berhampur, Odisha, IndiaPublications
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Research
Studies of Inclusion Complexes of 4-Thiazolidinone Derivatives with β-Cyclodextrin Characterization, Phase solubility and inclusion mode
Author(s): Simanchal Dash*
4-Thiazolidinone and its derivatives attracted large attention owing to its diverse pharmaceutical applicability and usefulness for the society. In this context, two important 4-thiazolidinone derivatives namely 2-o-chloro phenyl 3-(benzothiazolyl-2’) hydrazono-5-arylidene-4-thiazolidinone and 2-o-chloro phenyl 3-(benzothiazolyl-2’) hydrazono-5-p-anisilidiene-4-thiazolidinone are synthesized from 2-hydrazinobenzothiazole taking as a origin material. However these compounds are less soluble and small degree of bio-accessible. To get rid out of the problem, inclusion complex of the compound has been prepared with β-cyclodextrin. From the changes in spectral characteristics, physical characteristics and antibacterial activities of the compounds and their respective inclusion complexes justify their formation. Thermodynamic parameters ΔG will predict the formati.. Read More»
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Citations : 15261
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