Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
Shridhar P Melkeri
Department of Chemistry, Sahyadri Science College, Kuvempu University, Shivamogga, Karnataka-577201, IndiaPublications
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Research Article
Synthesis, Characterization and Biological studies on 3d-metal complexes of 5-[(1, 5-dimethyl-3-oxo-2-phenyl-2, 3-dihydro-1H-pyrazol-4-yl) diazenyl]-1-ethyl-6-hydroxy-4-methyl-2-oxo-1, 2-dihydropyridine-3-carbonitrile
Author(s): Shridhar P Melkeri, Parameshwara Naik*, G. Krishnamurthy, Prabhaker Walmik and Priyarani RS
N-hetorocyclic ligand 5-[(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl) diazenyl]-1-ethyl-6-hydroxy-4-methyl-2-oxo-1,2Dihydropyridine-3-carbonitrile (L) and a few of their transition metal complexes have been synthesised and characterized by different physico-chemical techniques. The electronic and magnetic susceptibility measurements suggest an octahedral geometry for all the complexes excepting Zn(II) complex which possess tetrahedral geometry. The results of thermo-gravimetric analysis showed that the synthesized complexes have thermal stability and confirms the absence of coordinated or lattice water molecules. The bio-potency of all these compounds was investigated by using antimicrobial, antimycobacterial and cytotoxic activities. All the transition metal complexes were noticeably exhibited inhibition properties against the tested microbes... Read More»
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