Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
Sanjeeb Kumar Sahoo
Department of Pharmaceutics, Centurion University of Technology and Management, Bhubaneswar, Odisha, IndiaPublications
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Research Article
In Vivo Assessment, Formulation, Characterization and Enhancing Pharmacotherapy of Encapsulated Mini Tablets for Immediate Release Sildenafil Citrate and Sustained Release Bosentan
Author(s): Deepak Kumar Sarangi*, Chandra Sekhar Patro, CH. Niranjan Patra and Sanjeeb Kumar Sahoo
The objective of the current study is to formulate encapsulated sildenafil citrate Immediate Release (IR) and Bosentan sustained release Minitablets (MTs) for treating pulmonary arterial hypertension. This piece of research work signifies a targeted dosage form that is designed in the form of encapsulated minitablets taking different super disintegrants and polymers which produces superior product quality. In vivo pharmacokinetic studies of prepared mini tablets are also showed promising results. Using different concentrations of polymers like HPMC K15M, ethyl cellulose and sodium CMC for Bosentan SR tablets, while for sildenafil citrate IR super disintegrants like sodium starch glycollate, magnesium aluminium silicate (Veegum-HV) and crosslinked PVP are taken for the manufacturing of MTs. All the pre compression and post compression parameters are carried out. The investigat.. Read More»
DOI: 10.4172/0975-413X.15.6.127-133
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Citations : 15261
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