Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
Samaneh Ebrahimi
Department of Psychology, Isfahan (Khorasgan) Branch, Islamic Azad University, Isfahan, IranPublications
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Research Article
Comparing the Effects of Cannabis and Paroxetine on Depressive Symptoms by Using Forced Swimming Test in Mice
Author(s): Samaneh Ebrahimi, Mehrdad Modaresi* and Ilnaz Sajjadian
Current study was carried out to compare the effects of cannabis and paroxetine on laboratory depressive symptoms of mice using forced swimming test. Sixty female mice from weight range of 25-30 were divided into 6 groups. Depression was enforced by injecting tetrabenazine. Hydroalcoholic extract of cannabis was injected intraperitoneal in 50, 100 and 200 mg/kg of weight, paroxetine was injected in ¼ mg/kg dose for paroxetine group and control group did not receive any thing to evaluate depression. Forced swimming test was used and increased movement time (in seconds) or reduced immobility time were used as depression indices. Multivariate covariance analysis showed that 50 and 100 mg/kg doses increased movement time and decreased immobility time in proportion to control and paroxetine significantly, which indicates depression reduction. Therefore, .. Read More»
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Citations : 15261
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