Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
Sagne Jacques Akpa
Laboratoire de Constitution et de Recherche de la Matière – UFR SSMT – Université Félix Houphouët, Boigny 22 B.P. 582 Abidjan 22, Cote D'IvoirePublications
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Research Article
Synthesis of 7- (Ethylaryl) Theophylline DDérivatives from Acyclovir
Author(s): Sagne Jacques Akpa*, GbeGondo Didier Diomande, Venance Martial Say and Ané Adjou
In the search for new antiviral drugs, we decided to synthesize new acyclovir derivatives which are widely used in the treatment of Herpes. This work consisted of exploring the positon-7 of theophylline by alkyl halides, which led to compounds 3a-b. The introduction of chloroaryl and thioaryl groups on the latter allowed to obtain compounds 5a-c and 7a-b. The chemical structures of all synthesized compounds were determined by 1 H, 13 C NMR and electron impact mass spectrometry... Read More»
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Citations : 15261
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