Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
Rashmi Tambare
Department of Pharmaceutics, Shreeyash Institute of Pharmaceutical Education & Research, Aurangabad, Maharashtra, IndiaPublications
-
Research Article
Development and Validation of Simplified RP-HPLC Method for Quantification of Candesartan Cilexetil in Commercial Formulations
Author(s): Sachin Kothawade*, Rashmi Tambare, Vishal Pande, Rucha Pardeshi, Sandesh Bole, Pranaya Misar, Balireddy Keesara, Prachi Kanawade, Kanchan Jadhav, Vijaya Padwal, Amit Lunkad and Manjusha Bhange
In order to produce antihypertensive effects, Candesartan Cilexetil (CC), a candesartan inactive prodrug, was quickly converted into active candesartan after absorption in the Gastrointestinal (GI) tract. This research study describes the development and validation of an accurate, precise, repeatable, easy and speedy Reverse-Phase High-Performance Liquid Chromatography (RP-HPLC) approach for measuring CC in a formulation using reverse-phase HPLC. In this study, liquid chromatography was performed on a Zorbax SB C-18 analytical column with dimensions of 2504.6 mm, 5 m, using a mobile phase consisting of Acetonitrile (ACN) and 0.1 percent orthophosphoric acid (pH 2.5) in a ratio of 35:65 vol/vol as the mobile phase. Results were presented as mean Standard Deviation (SD). This experiment used an injection volume of 20 microliters to measure the sample at 258 nano liters.. Read More»
DOI: 10.4172/0975-413X.16.1.197-203
Select your language of interest to view the total content in your interested language
Google Scholar citation report
Citations : 15261
Der Pharma Chemica received 15261 citations as per Google Scholar report
Der Pharma Chemica peer review process verified at publons
