Rashid Azeez

Department of Clinical Biopharmacological Analysis & Quality Assurance Techniques, Royal college of Pharmaceutical education and Research (S.P. Pune University), Sayne, Malegaon (Nasik) ,423203 Maharashtra, India

Publications

Research Article
A Novel Validated High Performance liquid chromatographic stability indicating assay method for the chemical analytical quantification of Norethindrone Tablets and their degradation study
Author(s): Rashid Azeez*, Masood Ahmed Siddiqui and Ziyaurrahman Azeez

Norethindrone is a synthetic chemical analogue of naturally occurring steroid whose structure is chemically based on a steroid nucleus-a hydrogenated cyclopentanoperhydrophenanthrene ring having 17 carbon atoms. This is new drug and vital in medicine. Tablet dosage form is new pharmaceutical formulation and used as oral contraceptive. They are low dose and have less label claim. The development and validation of assay method by RP-HPLC-DAD is challenging and not yet reported. The objective of this research was to develop and validate a precise, efficient, specific, accurate and stability indicating RP-HPLC-DAD assay method for the quantification of Norethindrone in Norethindrone tablets and their forced degradation studies. This HPLC method developed have a reverse phase Inertsil ODS-3V, 150 x 4.6mm, 5μ column, a mixture of amine buffer pH 2.5 and acetonitrile as mobile phase in is.. Read More»

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