Ramakrishna K

APL Research Centre (A Division of Aurobindo Pharma Limited), Hyderabad-500072, Telangana, India

Publications

• Research Article   
  UPLC Method for the Quantification of Elvitegravir, Cobicistat, Emtricitabine and Tenofovir Disoproxil Fumarate in Tablets Using OGD Reference Dissolution Medium
  Author(s): Vittal SP, Rao SM and Ramakrishna K*
  
  The current paper discuss about strategic development and validation activity performed for quantification of Elvitegravir (EL), Cobicistat (CO), Emtricitabine (EM) and Tenofovir Disoproxil fumarate (TDF) in a combination drug product using Office of Generic drugs (OGD) recommended Dissolution medium. Ultra Performance Liquid Chromatographic (UPLC) technique method was chosen and developed a method with a run time of four minutes. Mobile phase A consists of 0.1% perchloric acid and Mobile phase B consists of Acetonitrile. Gradient elution technique was opted with an optimized flow rate of 0.3 ml per minutes. Acquity UPLC BEHC18 (100 mm × 2.1 mm ID), 1.7ï�?�??�?­ particle size column is finalized for testing purpose with a detection wavelength of 260 nm. Typical retention times observed for EM, TDF, CO and EL are 0.89, 1.42, 2.01 and 2... Read More»
  

  Abstract HTML PDF

30+ Million Readerbase

Google Scholar citation report

Citations : 15261

Der Pharma Chemica received 15261 citations as per Google Scholar report

Der Pharma Chemica peer review process verified at publons