Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
Purbasha Saha
Department of Biomedical Sciences, School of Bioscience and Technology, VIT University, Vellore, Tamil Nadu-632014, IndiaPublications
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Research Article
In-Vitro Alpha-Amylase Inhibitor Activity and Antioxidant Activity of Actinobacteria Isolated from Marine Sediment Samples
Author(s): Elizabeth Mathew, Haimanti Mondal, Priyanka Kharat, Purbasha Saha and KV Bhaskara Rao*
Marine environment is a diverse and untapped source of a wide variety of biologically active compounds. Among several organisms, marine actinomycete has been known to be a potential source for novel enzymes. Diabetes mellitus is a long term metabolic disorder characterized by hyperglycaemia. In the present study, marine actinobacteria isolated from the marine sediments of the coastal areas of Kothapattanam, Ongole, Andhra Pradesh, were used to screen for alpha-amylase inhibitor and antioxidant compounds, which are known to manage type 2 diabetes. A total of 20 actinobacteria were isolated from the marine sediments. Among the 20 isolates, an actinobacterial isolate designated VITMA1 showed 58.16% inhibition against alpha amylase enzyme. Further, VITMA1 also exhibited antioxidant activity. It showed 61.82% of DPPH radical scavenging activity, reducing power .. Read More»
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