Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
Papichettypalle Gopinath
Department of Pharmaceutical Chemistry, GITAM School of Pharmacy, GITAM University, Hyderabad, IndiaPublications
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Review Article
Triazole Benzene Sulfonamides as Leads for Human Carbonic Anhydrase IX Inhibition: Updates on Research Progress
Author(s): Papichettypalle Gopinath*
Introduction: Triazole moiety is considered as the most important heterocyclic therapeutic agent in medicinal chemistry. Identifying a lead compound or potential drug, with the requisite physical and biological characteristics from a library of known bioactive molecules is the first step in the traditional drug development process which involves identifying the protein target associated with the disease. This severely restricts the search space from the outset and makes the task of discovering new drugs (or novel chemical structures) very challenging. Areas covered: This review discusses triazole derivatives possessing anticancer activity (hCA inhibition) and also illustrates the recent updates on triazole moiety for hCA inhibition research emphasizing the structure activity relationship aspects. Conclusion: However, a.. Read More»
DOI: 10.4172/0975-413X.16.2.274-282
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