Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
Oluwaseyi Febenna Eko
Department of Microbiology, Laboratory of Molecular Biology, Immunology and Bioinformatics, Adeleke University, P.M.B. 250, Ede, Osun State, NigeriaPublications
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Research
In-Silico Prediction of T- cell epitopes in VacA: First Step towards the Design of a Helicobacter Pylori Vaccine
Author(s): Elijah Kolawole Oladipo*, Abisola Temiloluwa Aina, Oluwaseyi Febenna Eko, Olubukola Monisola Oyawoye, Boluwatife Ayobami Irewolede and Temitope Isaac Adelusi
Helicobacter pylori are indicated in gastritis, gastric cancer, Peptic ulcer and B cell mucosa lymphoid tissue lymphoma. The bacteria have a 50% pandemic, a higher prevalence of 75% in developing countries and 40% in developed countries. A combination of antibiotics is used to treat Helicobacter pylori infections. Some of these are Amoxicillin, tetracycline, and fluoroquinolones, but are ineffective in eliminating the infections and are also compromised by antibiotic-resistant strains, therefore a vaccine to help prevent, control and eliminate Helicobacter pylori infections is needed. We proposed to predict T-cell epitopes of VacA. Seven VacA protein sequences were retrieved from the NCBI protein database and subjected to antigenicity test using the ANTIGENpro database. All the seven (7) sequences with antigenicity score ≥0.8 were submitted to the NetCTL .. Read More»
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Citations : 15261
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