Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
Nemat A Yassin
Pharmacology Department, National Research Centre, Dokki, Giza, EgyptPublications
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Research Article
Regulatory Effects of Morus alba Aqueous Leaf Extract in Streptozotocin-Induced Diabetic Nephropathy
Author(s): Abeer AA Salama, Bassant MM Ibrahim, Nemat A Yassin, Sawsan S Mahmoud, Amina A Gamal El-Din and Nermeen A Shaffie
This study aimed to investigate the effects of aqueous leaf extract of Morus alba on biochemical and histological changes in streptozotocin (STZ)-induced diabetic nephropathy. Male Wister albino rats were divided into five groups of six each: Group 1: Control group; received citrate buffer for 10 days. Group 2: Untreated diabetic rats injected intraperitoneally with 50 mg/kg of STZ; received distilled water for 10 days. Group 3-5: Diabetic rats; received Glimepiride and M. alba in 2 dose levels (250 and 500 mg/kg) for 10 days, orally. STZ-diabetic rats exhibited hyperglycemia accompanied with increased α-amylase levels, total cholesterol (TC) and kidney function, on the other hand, reduced high density lipoprotein cholesterol (HDL-C) and total antioxidant capacity (TAC) levels. Morus alba in its 2 dose levels (250 and 500 mg/kg) showed a significant .. Read More»
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