Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
Kathirvel S
National College of Pharmacy, KMCT Group of Institutions, Manassery, Kozhikode-673602, Kerala, IndiaPublications
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Short Communication
UPLC method Validation for bioanalysis of Gemcitabine in rat PK study using VAMS methodology (Volumetric Absorptive Microsampling)
Author(s): Raja Rajeswari K*, Hafis Jamal Ayyil and Kathirvel S
Volumetric absorptive microsampling (VAMS) is a simple intuitive technique for collecting and quantitative analysis of dried blood samples. It enables the collection of an accurate blood volume regardless of blood hematocrit. A bioanalytical method for the determination of gemcitabine in dried blood supported on VAMS samplers has been validated and used to support a pharmacokinetic study in rat. The calculated PK parameters were comparable to those obtained from blood–water (1:1, v/v) samples. VAMS is demonstrated to be a robust method that simplifies both the blood sample collection and bioanalytical laboratory procedures and generates high quality quantitative data. Waters Acquity UPLC system using an Acquity BEH C18 column (100x2.1 mm, 1.7 μm) was used for chromatographic separation by isocratic elution using acetonitrile-water (35-65) as the mobile phase at a flow rate of.. Read More»
DOI: 10.4172/0975-413X.15.3.38-51
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