Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
Kalpana Chaturvedi
Department of Chemistry, Agra College, Agra, IndiaPublications
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Research
Novel Synthesis of Some Organophosphorus Derivatives as Chemotherapeutants against Fungal Pathogens of Sugracane
Author(s): Kalpana Chaturvedi* and Smita Chaturvedi
The reactions of O,O-diethylchlorophosphate or O,O-diethylchlorothiophosphate with 1,4-phthalazine-bis(hydrazones), derived by the condensation of 1,4-dihydrazinophthalazine dihydrochloride monohydrate and 2-hydroxy benzaldehyde/4-hydroxy benzaldehyde/2- hydroxyacetophenone/4-hydroxyacetophenone, have been studied and a variety of organophosphorus derivatives have been obtained. The derivatives have been characterized on the basis of analyses and spectral (IR, 1H NMR) data and tested for their antifungal efficacy against colletotrichum falcatum, Fusarium oxysporum and Curvularia pallescens (all sugarcane pathogens). These compounds show promising results in inhibiting the mycelial growth of all the test fungi at 1000 ppm. Out of these, the most active compound is 0,0-diethylthiophosphate derivative containing 1,4-phthalazine-bis(2-hydroxyacetophenone) hydrazone(VII),which shows ac.. Read More»
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