Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
Jyoti Srivasata
Babasaheb Bhim Rao Ambedkar University, Lucknow, Uttar Pradesh 226025, IndiaPublications
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Research Article
Designing, Synthesis and characterization of novel Substituted pyrazol-azetidin-2-one/thiazolidin-4-one derivatives for their antimicrobial activity
Author(s): Krishna Srivastava*, Raj Bahadur Singh, Jyoti Srivasata and Dinesh Gupta
This research work includes the synthesis of (3-hydroxy-4-methoxyphenyl)-3-((1-(5-(2-nitrophenyl)-3-phenyl-4,5-dihydro-1H-pyrazol-1-yl) ethylidene)amino)thiazolidin-4-one(VIIa-f)/3-chloro-4-(substitutedphenyl)-1-((1-(5-(2-nitrophenyl)-3-phenyl-4,5-dihydro-1H-pyrazol1yl)ethylidene) amino) azetidin-2-one(VI a-f) having a pyrazol ring, obtained from the reaction of hydrazine hydrate with chalcone along with athiazolidinone ring/azetidinonemoeity, procured after the cyclization of a schiff base by thioglycolic acid/Chloroacetyl chloride. The structure of the synthesized compounds has been established on the basis of elemental analysis, UV-Vis absorption spectroscopy, IR, 1HNMR, and mass spectral studies. The in vitro antimicrobial screening of all the novel compounds was done against S.aureus, E.coli, P.aeruginosa and B. subtilis. The activity of VIb, VIf, VId and VIIa, VII.. Read More»
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