Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
Jeshma Kovvuri
Vardhaman College of Engineering (Autonomous), Hyderabad, Telangana, IndiaPublications
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Research Article
Visible Light Photoredox-Catalyzed Synthesis of Quinazolinone Derivatives and their cytotoxicity
Author(s): Jeshma Kovvuri*
Visible light promoted efficient and eco-friendly photocatalytic method for the synthesis of quinazolinones. This protocol involves commencing readily available substituted isatins and 2-aminobenzamide by using Rose Bengal as an efficient recyclable photocatalyst. This method is operationally simpler and selective, carried out in shorter reaction time with visible light in higher yields. Using this protocol, a series of twenty compounds has been synthesized, all the synthesized compounds were evaluated for their cytotoxic potential on three human cancer cell lines and most of the compounds exhibited moderate to good cytotoxic activity, while some of them showed promising cytotoxicity with IC50 values ranging between 1.13 μM-1.77 μM... Read More»
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