Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
Hari Prasad Sonwani
Department of Pharmacology, Apollo College of Pharmacy, Anjora Durg C.G, IndiaPublications
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Review Article
Changes in the Vascular Expression of Na+ , K + ATPase and Contractions Generated by Phenylephrine in Ouabain Induced Hypertension
Author(s): Hari Prasad Sonwani*
In rats treated with ouabain (25 mg day 71, s.c., 5 weeks) or vehicle, the development of hypertension, contraction produced by phenylephrine and Na+, K+-ATPase functional activity and protein expression were assessed in the Aorta (AO), Tail (TA) and Superior Mesenteric (SMA) arteries. Ouabain therapy raised systolic blood pressure (127+1 vs. 160+2 mmHg, n=24, 35; P50.001), although in AO (102.8+3.9 vs. 67.1+10.1% of KCl response, n=12, 9) and SMA (82.5+7.5 vs. 52.2+5.8%, n=12, 9), the maximal response to phenylephrine was decreased (P50.01). In segments from rats treated with ouabain, the phenylephrine response was more strongly enhanced by endothelium ablation. Consequently, for control and ouabain treated rats, the Differences in the Area Under the concentration-response Curves (dAUC) in endothelium-denuded and intact segments were, .. Read More»
DOI: 10.4172/0975-413X.15.6.119-121
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Citations : 15261
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