Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
Hanan F. Aly
Department of Therapeutic Chemistry, National Research Centre, Dokki 12622, Giza, EgyptPublications
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Research Article
Healing Potency of Citrus, Hesperetin and Naringenin Loaded with Silicate Nanoparticles on Neurotoxicity Induced by Acrylamide Toxic Dose
Author(s): Maha Z. Rizk, Abo-elmatty D.M, Hanan F. Aly, Howaida I. Abd-Alla, Samy M. Saleh and Eman A.Younis
The current research demonstrated the effect of silica loaded nanoparticles (citrus, naringenin and hesperetin) on acrylamide (ACR) intoxicated rats, through measuring specific selected biomarkers on brain. Brain neurotransmitters noradrenaline (NA), adrenaline (A), dopamine (DA) and serotonine (5-HT), acetylcholine esterase (ACHE) andcaspase-3 enzyme activity and DNA degradation (Comet) were evaluated. ATPase enzyme activity and total protein content were also evaluated. Besides, the presented data showed significant deterioration in the all selected biomarkers investigation in aclylamide-intoxicated rats. It showed significant reduction in brain neurotransmitters (NAADA and 5-HT), ATPase enzyme activity and total protein content while significant elevation in AchE and Caspase-3 enzyme activity and DNA damage. Treatment of intoxicated rats with the three .. Read More»
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Citations : 15261
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