Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
Guguloth Ravi
Department of Chemistry, University College of Science, Osmania University, Hyderabad, Telangana-500 007, IndiaPublications
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Research Article
Synthesis, Characterization of Diethylamino Benzylidene-5-Methyl-2-Phenyl-Pyrazol-3- One Substituted 1,2,3-Triazoles and Evaluation of their Anti-Microbial Activity
Author(s): Dharmasothu Veeranna, Lakavath Ramdas, Guguloth Ravi, Anil Kumar Bojja and Ramchander Jadhav*
A new series of (Z)-4-(4-(diethylamino)-2-((1-phenyl-1H-1,2,3-triazol-4-yl)methoxy)benzylidene)-3-methyl-1-phenyl-1H-pyrazol-5(4H)-one (5a-l)ha been synthesized by the reaction of (Z)-4-(4-(diethylamino)-2-(prop-2-yn-1-yloxy)benzylidene)-3-methyl-1-phenyl-1H-pyrazol-5(4H)-one with different aromatic azides. Chemical structures of all the new compounds were established by IR, 1H-NMR, 13C NMR, MS and elemental data. The Compounds 5a-l were evaluated for their antibacterial activity against Gram-positive bacteria viz Bacillus subtilis(MTCC 441), Bacillus sphaericus (MTCC 11),Staphylococcus aureus (MTCC 96), and Gram-negative bacteria viz. Pseudomonas aeruginosa (MTCC 741), Klebsiella aeroge(MTCC 39), Chromobacterium violaceum (MTCC 2656). Amongst them, compounds containing 5b[1-(4-bromophenyl)-1H-1,2,3-triazol-4-yl)], 5d[(1-(4-chlorophenyl)-1H-1,2,3-triazol-4-yl)], 5j [(1-(3-acetylphenyl.. Read More»
DOI: 10.4172/0975-413X.15.1.13-20
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