Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
Fajrian Aulia Putra
Faculty of Medicine, Fort de Kock University, Jl Dr Hamka no 101, Bukit Surungan, Padang Panjang, IndonesiaPublications
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Research Article
Acute Toxicity Test of Standardized Ethanol Extract of Gandasuli Rhizome (Hedycium coronarium) and histopathology of organs in white mice male (Mus muculus)
Author(s): Fajrian Aulia Putra* and Netty Suharti
Gandasuli (Hedycium coronarium.) is one of the native plants of Indonesia which It has been used as medicine by generations of people from generation to generation. This study aims to determine the acute toxicity of standardized ethanol extract of gandasuli rhizome (Hedycium coronarium) against male white mice, Swiss webster strain. The method used is to determine the value of Ld 50 using the Thompson-weil method. In this study, the parameters observed were the toxicity value of the standardized ethanol extract of gandasuli rhizome based on the Ld 50 value, histopathology of the liver and kidneys. A total of 25 male Swiss Webster white mice were randomly divided into 5 groups, namely group 1 as a control, group 2 treated with ethanol extract of gandasuli rhizome at a dose of 4 g/KgBW, group 3 at a dose of 8 g/Kg BW, group 4 with a dose of 16 g/Kg BW and group 5 with a dose of 32 g.. Read More»
DOI: 10.4172/0975-413X.14.8.55-60
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