Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
Ebuka Leonard Onyeyilim
Department of Chemistry, University of Iowa, USAPublications
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Research
ADVANCES IN BENZOTHIAZOLE SCAFFOLD: A REVIEW OF SYNTHESIS AND MEDICINAL SIGNIFICANCE
Author(s): Vivian Ifeoma Okonkwo, Chinedu Emmanuel Nnadi and Ebuka Leonard Onyeyilim*
A large number of bioactive heterocycles have been synthesized and reported to exhibit a wide range of biological properties including anticancer, antimicrobial, antidiabetic, anticonvulsant, anti-inflammatory, antiviral, antitubercular activities. In recent years there have been some interesting developments in the biological activities of benzothiazole derivatives. These compounds have special significance in the field of medicinal chemistry due to their remarkable pharmacological potentialities. The heterocycles bearing benzothiazole nucleus were synthesized using One-pot synthetic approach, which involved One-pot condensation of 2-aminothiophenol with different aromatic aldehydes, alcohols and carboxylic acids. Microwave promoted Suzuki-Miyaura coupling approach and Catalytic synthetic methodology were also employed in this synthesis. This review does not only disclose facile synt.. Read More»
DOI: 10.4172/0975-413X.15.5.1-28
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