Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
Dhanaraju Magharla Dasaratha
Department of Pharmaceutical Technology. GIET School of pharmacy, Rajahmundry, AP, IndiaPublications
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Research Article
NOVEL CLARITHROMYCIN LOADED SELF EMULSIFYING DRUG DELIVERY SYSTEM FOR AMPLIFICATION OF SOLUBILITY AND ORAL BIOAVAILABILITY
Author(s): Sundar Vankayala Devendiran*, Vijayalakshmi Rajendran and Dhanaraju Magharla Dasaratha
SEDDS (self-emulsifying drug delivery system) are of particularly relevant for the production of isotropic mixtures of oil, surfactant, co-surfactant, and drug in order to solve their physicochemical problems. Clarithromycin (CLA), a macrolide, has a 50 percent absolute bioavailability. The goal of this work was to create a liquid SEDDS system for CLA in order to increase solubility by increasing interfacial surface area and thereby boosting absorption. Clarithromycin SEDDS were produced with isopropyl myristate as the oily phase, Cremophor EL, Tween 80, Brij 58 as surfactants, and isopropyl alcohol, isobutanol, and transcutol EL as co-surfactants. Clarithromycin solubility was studied in a variety of vehicles, including isopropyl myristate, Cremophor EL, brij 58, tween 80, isopropyl alcohol, isobutanol, and transcutol RH, with isopropyl myristate yielding around 112.35 mg/ml. Formula.. Read More»
DOI: 10.4172/0975-413X.15.4.5-13
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Citations : 15261
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