Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
Defne Ay Tuncel
Department of Pediatric Hematology, Adana City Training and Research Hospital, Adana, TurkeyPublications
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Research Article
The Efficacy of Camptothecin Variants on Incidental Relapsed/Refractory Malignancies of Childhood
Author(s): Defne Ay Tuncel* and Ganiye Begul Kupeli
In this study, we aimed to assessed the effect of camptothecin derivatives (irinotecan and topotecan) on median survival and disease-free survival and their effect on treatment responses in relapsed/refractory patients in real-life settings. In our study, we retrospectively evaluated patients under the age of 18 who were followed up in paediatric haematology clinics with the diagnosis of relapsed/refractory wilms tumour, neuroblastoma, osteosarcoma, ewing sarcoma and Medulloblasoma (MB) between 2017 and 2022. Patients who received irinotecan as salvage therapy were included in the study. A total of 71 patients from a single centre in Turkey were included in the study. All patients received at least 2 lines of treatment before relapse/refractoriness. Median overall survival times according to the response groups obtained with Campthotesin were statistically significant (p<0.001). Me.. Read More»
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