Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
Dagne Addisu Kure1
Department of Chemistry, Hawassa University, Hawassa, EthiopiaPublications
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Research Article
Synthesis, characterization and antibacterial activity of Schiff base of Cu (II), Ni (II) and Co (II) complexes
Author(s): Salah Hamza Sherif*, Dagne Addisu Kure1, Endalkachew Asefa Moges and AkmalNur Negash
Due to their importance as catalysts in many reactions and their biological activities, an interest in the synthesis and characterization of transition metal complexes containing Schiff bases is increasing. The major aim of this study was to compare the antibacterial activity of the ligands with their metal complexes. We have successfully synthesized Cu (II), Ni (II) and Co (II) complexes of N, N-Bis(vanillinidene )-1,2-phenylenediamine and N,N-Bis(salicylidene)-1,2-phenylenediamine. The Schiff’s bases were synthesized by the reaction of o-phenylenediamine with salisaldehyde or o-vanillin and their metal complex were synthesized by the reaction of the ligands with the metal salts. The structure of all the synthesized ligands were confirmed using NMR, IR and UV-Vis spectral analysis and their metal complexes were confirmed using IR and UV-vis spectra. The synthesized ligands and .. Read More»
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