Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
Dagne Addisu
Department of chemistry, Hawassa university natural and computational science, EthiopiaPublications
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Review Article
Synthesis, Characterization and Antibacterial Activity of Indole Based-Chalcone Derivatives
Author(s): Salah Hamza*, Dagne Addisu and Yenealem wagew
Indole-based chalcone derivatives were synthesized via the reaction of indole and 5-bromo-indole with phosphoursoxychloride in the present of DMF to form formayl indole using Vilsmeyer Haack formylation reaction and the intermediate compound were formed by using condensation reaction. Finally cyclization reaction to get the target compound. The structure of all the synthesized compounds were elucidated by spectral analysis using IR, 1H NMR, and 13C NMR, spectrometer, The synthesized compounds were also evaluated for their antibacterial activities against three bacterial strains using agar well diffusion method and their antibacterial activity were screened for against gram positive bacteria staphylococcus aureus and gram-negative bacteria Klebsiella pneumonia, and Escherichia coli bacterial species. The synthesized chalcone 3-(4,5-dihydro-1,3-diphenyl-1H-pyrazol-5-yl)- 1Hindole was fo.. Read More»
DOI: 10.4172/0975-413X.14.9.12-15
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