Chakole RD

Department of Pharmaceutical Chemistry, Government College of Pharmacy, Vidyanagar, Karad, Dist.: Satara Pin- 415124, Maharashtra, India

Publications

• Research   
  Development of Stability Indicating Assay Method for Estimation of Olmesartan Medoxomil and Chlorthalidone in Its Combined Dosage Form
  Author(s): Anekar VP*, Charde MS and Chakole RD
  
  Performance liquid chromatographic method was developed for estimation of two Anti-hypertensive drugs, Olmesartan medoxomil and Chlorthalidone. The separation of both the drugs was achieved on Phenomenex kinetex XB C-18 column (150 mm X 4.6 mm , 5μ particle size) using mobile phase Acetonitrile : 0.1% TFA Water (45:55v/v). The flow rate was 1 ml/ minute with run time 10 minutes and detection was done at 235 nm. The retention time of Olmesartan medoxomil and for Chlorthalidone was 2.15 min. and 1.71 min. respectively. The linearity of the method was evaluated at a range of 50 to 150 μg/ml and 31.25 to 93.75 μg/ml for Olmesartan medoxomil and Chlorthalidone respectively. The Correlation Coefficient of Olmesartan medoxomil and Chlorthalidone were 0.999 each. Precision studies were carried out and %RSD of peak areas of Olmesartan medoxomil and Chlorthalidone was about 0.051 and 0.. Read More»
  DOI: 10.4172/0975-413X.15.4.14-23

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