Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
Basava Rao VV
Department of Pharmacy, University College of Technology, Osmania, Hyderabad-500007, Telangana, IndiaPublications
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Research Article
STABILITY INDICATING RP- HPLC METHOD FOR SIMULTANEOUS ESTIMATION OF SALICYLIC ACID AND KETOCONAZOLE IN SHAMPOO FORMULATION
Author(s): Dilip Kowndinya B*, Basava Rao VV and Sailu CH
A reverse phase HPLC method was developed and validated for the simultaneous estimation of Salicylic acid and Ketoconazole in shampoo formulation. Separation of the drugs was done using Kromasil C18 (250×4.6mm, 5μ) column at 322 nm using a mobile phase comprising of Acetonitrile: Buffer (0.01 N Potassium dihydrogen orthophosphate adjusted to a PH of 5.4 using dilute Orthophosphoric acid) in the ratio of 50:50 at a flow rate of 1.0 mL/min. Retention times of Salicylic acid and Ketoconazole were found to be 2.307 min, 3.342 min respectively. Method was found to be linear in the range of 5-30 μg/ml. Developed method was validated and stability studies were performed according to ICH guidelines and applied for the assay of the drugs in the shampoo formulation... Read More»
DOI: 10.4172/0975-413X.15.3.70-79
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