Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
Bana DJ
NigeriaPublications
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Research Article
Comparative Evaluation of the Physicochemical and In Vitro Dissolution Properties of Some Expired and Unexpired Brands of Metformin Tablets
Author(s): Jacob A Kolawole* and Bana DJ
The comparative evaluation of the physicochemical properties and in vitro dissolution of some expired and unexpired brands of metformin tablets, six brands of expired (serial 1)and also unexpired (serial 2) of the same brand were used. The samples were determined using thin layer chromatography (TLC). Pharmacopoeia tests such as uniformity of weight, hardness, friability and assay were used to assess the physicochemical equivalence of the expired and unexpired metformin tablet brands. In vitro dissolution testing was conducted for both the expired and the unexpired tablets. All the brands (expired-serial 1) and (unexpired-serial 2) conformed to the British pharmacopoeia standard. All brands complied except C1 and F1 (within the range of not more than 1% (BP 2013) therefore brand C1 and F1 failed the friability test, the unexpired brand has higher crushing strength than the expired bra.. Read More»
DOI: 10.4172/0975-413X.15.1.21-29
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