Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
Ayman R Awad
Arab Drug Company, El-Amyria, Cairo, EgyptPublications
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Research Article
Design, Synthesis, Cytotoxicity, Physicochemical and In Vivo Studies of New Thalidomide Dithiocarbamate Analogs as Anticancer
Author(s): Magdy AH Zahran*, Ayman R Awad, Ahmed BM Mehany and Roba Talaat
Novel thalidomide dithiocarbamate analogs were synthesized in good yield. A two-step synthesis was utilized to obtain the new thalidomide dithiocarbamate analogs by reaction of thalidomide with 1,2 dichloroethane or 1,3 dichloropropane producing chloroethyl thalidomide 2 or chloropropyl thalidomide 3 compounds respectively, which reacts with Sodium diethyl dithiocarbamate to afford thalidomide dithiocarbamate 4 or 5. The chemical structures of all synthesized compounds were elucidated on the basis of their spectral IR, 1H NMR, 13C NMR, Mass spectroscopy and elemental analysis. The anticancer nature of thalidomide and thalidomide analogs 2-5 was evaluated by screening the in vitro activity on three human cancer cell lines; human lung cancer cells (A-549), human liver cancer cells (HEGP-2) and human breast cancer cells (MCF-7). Also the in vivo a.. Read More»
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