Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
Ashish Jain
Department of Pharmacy, LNCT University, Bhopal, IndiaPublications
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Research
Fabrication and Characterization of Cefixime Containing Micro Emulsion for Parenteral Drug Delivery System
Author(s): Ashish Jain*, Bhushan Hatwar and Akhlesh Kumar Singhai
The development of an injectable or parenteral micro emulsion formulation of the antibiotic cefixime was the aim of this investigation. We identified cefixime, which is easily soluble in methanol and propylene glycol and just slightly soluble in ethanol and acetone. Cefixime is directly dissolved in the aqueous buffer to create organic solvent-free aqueous solutions for use in biological experiments. To define the limits of a micro emulsion’s existence, pseudo ternary phase diagrams of oil, surfactant, cosurfactant (butanol/isopropyl alcohol mixture) and water were created. Cefixime was added to the ideal micro emulsion composition at 3, 6 and 9% w/w. We assessed the conductivity, solution viscosity and particle size of the cefixime micro emulsion. After being diluted in 5% dextrose for injection with 1 mg/ml cefixime, the micro emulsion’s stability and hemo.. Read More»
DOI: 10.4172/0975-413X.16.2.293-300
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