Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
Anil S Patil
Department of Chemistry, S.S.V.P.S. L.K. Dr. P.R. Ghogrey Science College, Dhule, Maharashtra, IndiaPublications
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Research Article
Synthesis and Characterization of Prodrugs of Sulfonamides as an Azo Derivatives of Carvacrol
Author(s): Shivaji M Koshti*, Prashant A Patil, Chetan B Patil and Anil S Patil
In the present work our goal was to explore the prodrug approach study especially for colon targeting antibacterial agents. We choose the sulfonamides as an antibacterial agent for colon targeting treatments. For this purpose sulfonamides were coupled to carvacrol through azo compound formation. The newly synthesized azo compounds were characterized by spectral techniques such as Infrared (IR), Proton Nuclear Magnetic Resonance (1H-NMR) and Carbon-13 Nuclear Magnetic Resonance (13C-NMR). The drug released study of the parent compound was done by in vitro enzyme degradation by using azoreductase enzyme which was secreted by pseudomonas aeruginosa bacterium. Carvacrol and its derivatives were known show remarkable biological activity such as antimicrobial, antitumor, antimutagenic, antigenotoxic, analgesic, antispasmodic, anti-inflammatory, angiog.. Read More»
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Citations : 15261
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