Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
Al Hafez M. Alraih
Department of Chemistry, College of Science, King Khalid university, Abha, KSAPublications
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Research Article
Antimicrobial Activity of 7, 3`, 4`-Trihydroxy flavonol Isolated from Acacia Nilotica Var. Adstringens
Author(s): Al Hafez M. Alraih, Mohamed A. Mohamed, Mohamed A. Alansari, Abu Baker M. Osman*, Khalda M. Ahmed, Ayda Y. Abdelrahman and Mohamed E. Hamid
Acacia species (Mimosaceae) is widely distributed in tropical and subtropical countries and has a variety of ethnomedicinal uses. There is inadequate laboratory investigation to identify bioactive compounds and therapeutic effect of Acacia nilotica var. adstringens. This research was conducted to extract, isolate and identify major compounds from heartwood of Acacia nilotica var. adstringens and to test them against representative bacteria. Powdered air-dried heartwood of A. nilotica var. adstringens was extracted with methanol/water, 4:1 and the extracted was then purified using chromatographic techniques (column and paper chromatography). A pure flavonoid compound was isolated and the structure was elucidated based on extensive spectroscopic analysis procedures (IR, UV, 1H-NMR, and MS spectrometery). The isolated compound was then evaluated for antimicrobial potential against Gram-n.. Read More»
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