Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
Ajaykumar Thankakan Vimala
Department of Pharmacy, Annamalai University, Annamalainagar-608 002, Tamil Nadu, IndiaPublications
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Research Article
In-Vitro Cytotoxic Effect of Linderina madayiparense Extracts against Human Lung Carcinoma Cell Lines (A-549)
Author(s): Umakrithika Chiranjeevi*, Anandarajagopal Kalusalingam, Ajaykumar Thankakan Vimala and Kannan Kamarajan
Lung cancer is one of the most lethal worldwide and has a dismal prognosis. This disease has become important as a public health concern. Conventional radio-chemotherapies cause adverse side effects ranging from gastro-intestinal complications to bone marrow failure. The inadequate availability of efficient and safe treatment for the cancer intends the scientific researchers to focus the phytochemicals derived from medicinal plants. Lindernia madayiparense (Family: Linderniaceae) is widely distributed in the laterite hills, Kerala, India. Petroleum ether, ethyl acetate and ethanol extracts of L. madayiparense were prepared by continuous hot extraction method using Soxhlet apparatus. All the extracts were assessed for their in-vitro cytotoxic effect against Human lung carcinoma cell lines (A-549 cell line) by MTT assay. The maximum cytotoxic effect (90.96%).. Read More»
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