Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
Adeosun IJ
Department of Microbiology, Laboratory of Molecular Biology, Immunology and Bioinformatics, Adeleke University, P.M.B 250, Ede, Osun State, NigeriaPublications
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Research
Exploring the Potentials of Campylobacter spp. Chaperone Proteins in the Design of B and T Cell Multi-Epitope Subunit Vaccine: An Immunoinformatics approach
Author(s): Kaka MO*, Adeosun IJ, Olotu TM, Oyebamiji AK, Ajayeoba TA and Oyawoye OM
Campylobacter has been reported to be the cause of community-acquired infection and is often presented in immunocompromised individuals as acute gastrointestinal illness. It is also often transmitted through undercooked poultry products. Campylobacter also causes significant morbidity, leading to huge cases of disability but limited mortality (there can be about 75,000 annual fatal cases). Heat shock proteins are defined as a group of highly conserved and regulated proteins which are known to play vital roles in enabling diverse organisms cope with physiological stress. Thus, this study used an immunoinformatic approach to design a multi-epitope based vaccine that is targeted against Campylobacter spp. and related infections using Heat shock protein sequences. Designed subunit vaccine was evaluated for its antigenicity, immunogenicity, allergenicity and phys.. Read More»
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Citations : 15261
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