Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
Acharyulu MLN
Department of Basic Sciences and Humanities, Ceturion University of Technology and Management, Andhra Pradesh, IndiaPublications
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Research Article
Spectrophotometric determination of Darunavir using NQS and Brucine meta periodate
Author(s): Acharyulu MLN*, Mohana Rao PVSR and Siva Rama Koti I
Two simple and sensitive spectrophotometric methods (A and B) for the assay of Darunavir (DNV), in pure and pharmaceutical formulations were developed. The method-A is based on the condensation reaction of DNV forming an orange-red colored Schiff's base of maximum absorption peak (λ max) at 444 nm with sodium 1,2-naphthaquinone-4-sulfonate (NQS) in an alkaline medium. The dimethoxy benzene nucleus of brucine is attacked by IO4- with the formation of O-quinone (Bruci quinone) which in turn undergoes nucleophilic attack on the most electron rich position of the coupler i.e., proton bearing amino group (primary amine of DNV), to give 1-mono substituted Bruci quinone derivative. The reaction mechanism in both methods were discussed. The absorbance of colored complex is found at 511nm. Beer's law is obeyed in the concentration range 10-60 μg/ml, 50-300 μg/ml, the M.. Read More»
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