Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
Aamir Javed
R&D Centre, VEM Biotech Pvt. Ltd. #468, 39th cross, 9th main, 5th block Jayanagar, Bangalore 560041, Bengaluru, Karnataka, IndiaPublications
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Research
Neuroprotective Effects of VEM-PD Nasal drops against MPTP- Induced Parkinsonâ??s Disease in Mice
Author(s): Muralidhar S Talkad*, Aamir Javed, Niranjan Koirala, Vijay Satish and Anil Kumar HV
Objective: VEM-PD nasal drops are made of a proprietary herbal blend with micro-emulsions and CNS & PD-beneficial Bio-Actives. Which looked into the potential protective mechanisms of VEM- PD Nasal drops on a mouse model of Parkinson's disease (PD) caused by 1-methyl-4- phenyl- 1,2,3,6-tetrahydropyridine (MPTP). Methods: PD Nasal Drops dose levels that are specific on the levels of glutathione and malondialdehyde in the brain, as well as the activities of antioxidant enzymes in the striatum, extracts of 2 drops twice and 2 drops three times each were administered orally for 15 days in a row until behavioral observations were made. Results: MPTP (20 mg/kg, ip) was administered twice daily for five days prior to behavioral observation. When combined with MPTP + VEM-PD 2 drops /3 times, the striatum's glutathione (GSH) levels and antioxidant enzyme activity returned to nearly.. Read More»
DOI: 10.4172/0975-413X.15.5.90-94
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Citations : 15261
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