Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
Aakanksha Sinha
Department of Pharmacy, Pt. Ravishankar Shukla University, Raipur, Chhattisgarh, IndiaPublications
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Review Article
In-Situ Gel Systems for Ocular Therapeutics: Unveiling the Impact of Polymer Selection
Author(s): Aakanksha Sinha*, Vishal Das, Ramakant Yadav and S. J. Daharwal
A major problem in ocular therapeutics is the attainment of optimal drug concentration at the site of action, which is mainly due to precorneal loss resulting in only a small fraction of the drug being ocularly absorbed. Ensuring the use of in-situ gel-forming technologies, the effective dose can be changed by altering the medication's retention duration in the eye. The "in situ gel" system has become one of the top cutting-edge drug delivery systems; its special "sol to gel" transition feature helps with the controlled and continuous release of medications. An in-situ gelling system is a formulation that, before it enters the body, stays in the liquid form but that, when subjected to specific physiological circumstances, transforms into gel form. Various polymers are subjected to in situ gel formation and could be employed f.. Read More»
DOI: 10.4172/0975-413X.16.1.224-231
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Citations : 15261
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