Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
Abstract
Validated visible spectrophotometric methods for determination of Zileuton in pharmaceutical formulation
Author(s): K. Vara Prasada Rao, M. Tanuja, Y. Srinivasa Rao and T. Hemant KumarThe present study describes two simple and selective spectrophotometric methods for the determination of zileuton in bulk and tablet formulation. Two methods were based on the oxidation of zileuton with ferric chloride followed by complex formation with 1, 10-Phenanthroline (Method A) and 2, 2’-Bipyridine (Method B). The resulting red colored chromogens are measured at 510 nm and 523 nm in the concentration ranges of 5-30 μg/ml and 5-30 μg/ml for method A and method B respectively. The proposed methods were applied successfully to determine zileuton in tablet form without interference from excipients present in pharmaceutical formulation. The results of analysis have been validated statistically and by recovery methods.
Select your language of interest to view the total content in your interested language
Google Scholar citation report
Citations : 15261
Der Pharma Chemica received 15261 citations as per Google Scholar report
Der Pharma Chemica peer review process verified at publons
