Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
Abstract
Validated spectrophotometric methods for simultaneous estimation of telmisartan and indapamide in pharmaceutical dosage form
Author(s): Ramesh L. Sawant , Manish A. Raskar, Raihan Ahmed, Sameer PawarTwo simple, sensitive, and validated spectrophotometric methods are developed for quantitative estimation of telmisartan and indapamide in tablet dosage form. Method I is based on the simultaneous equation whereas Method II on the multicomponent analysis. The absorption maxima were found to be at 296 nm and 242 nm in methanol for telmisartan and indapamide respectively. Beer's law is obeyed in the concentration range of 5-25 μg/ml for telmisartan and 10-30 μg/ml for indapamide with correlation coefficient within range of 0.996 - 0.998 for both the drugs. The simultaneous equation method is based on the additivity of absorbances and multicomponent analysis involves recording absorbance of standard solutions at 296 nm and 242 nm. Both the methods are tested and validated for various parameters according to ICH guidelines and can be used for routine analysis of both the drugs in quality control laboratories.
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