Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
Abstract
Utility of 4-arylidene-3-methyl-1H-pyrazole on Michael Addition reactions for biological evaluation
Author(s): Hayam H. Sayed*, Hebat-Allah S. Abbas**, Eman M. H. Morsi, Eman M. FlefelAs an effort to synthesize new heterocyclic compounds, which would expected to have pharmacological and biological activities. We report here the reactivity of 1H-indazole-5- carboxamide 2, as Michael acceptors under different conditions, towards different Michael donors namely, hydrazine hydrate, hydroxylamine hydrochloride and O-phenylene diamine forming adducts 4 – 8. Pyrazolopyrimidine derivative 9 used as precursor for preparation some fused heterocyclic compounds 10 – 12. The structures of the products obtained were confirmed by elemental analysis, IR, 1HNMR, 13C NMR and mass spectra. The biological activities for some synthesized products are screened.
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Citations : 15261
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