Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
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Abstract
Utility of 2-cyano-N-(1-(4-morpholinophenyl)ethylidene)aceto hydrazide for the synthesis of some new acrylohydrazide, 2-oxo-1,2-dihydropyridine, bispyridine and chromene derivatives as potent antimicrobial agents
Author(s): M. H. HelalHydrazine derivative 2 underwent a series of hetrocyclization reactions through its reaction with different chemical reagents to produce acrylohydrazide, pyridine, bispyridine and chromene derivatives. The structure of the newly synthesized compounds was confirmed on the basis of analytical and spectral data. Antimicrobial activity for the newly synthesized products were tested against Gram positive bacteria and Gram negative bacteria and Fungi, compared with Amphotericin B, Ampicillin and Gentamycin as reference drugs.
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Citations : 15261
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