Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
Abstract
Tremendous effect of Salsola tetrandra and Salsola baryosma on a liver toxicity using paracetamol overdose
Author(s): Ahlam H. Mahmoud, Mahmoud S. Soliman, Nadia S. Metwally, Abdel-Razik H. Farrag, Fatma S. Elsharabasy, Sherifa Arafa and Amr M. M. IbrahimThe study was conducted to compare the defensive role of Salsola tetrandra and Salsola baryosma plant extracts against paracetamol-instigated intense hepatorenal toxicity in rats. Toxicity was stimulated by administration of a single oral dose of paracetamol (3 g/kg body weight). The extract of the aerial parts of plants (100 mg/kg) was utilized on a pre-and post-treatment basis. Both extracts significantly ameliorate liver and kidney functions with the prophylactic (pre) or therapeutic (post) treatments. Other biochemical markers as malondialdehyde (MDA) content, serum paraoxonase-1(POX-1) enzyme activity interleukin-1(IL-1β) and tumor necrosis factor alpha (TNF-α) level were also reduced. Histopathological and histochemical studies showed parallel effects with the biochemical measured. Both extracts seem to have a plethora of antioxidative compounds with marked effect against paracetamol-induced hepatorenal toxicity in rats. Salsola tetrandra was more potent than S. baryosma on the basis of all measured parameters.
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