Thermal, physico-chemical, in vitro anti-microbial and DNA cleavage investigations of newly synthesized Co(II), Ni(II) and
Cu(II) complexes of O, N donor Schiff base

Sangamesh A. Patil; Bhimashankar M. Halasangia; Shivakumar S. Toragalmatha; Prema S. Badamib

Abstract

Thermal, physico-chemical, in vitro anti-microbial and DNA cleavage investigations of newly synthesized Co(II), Ni(II) and Cu(II) complexes of O, N donor Schiff base

Author(s): Sangamesh A. Patil, Bhimashankar M. Halasangia, Shivakumar S. Toragalmatha, Prema S. Badamib

Cobalt(II), Nickel(II), Copper(II) complexes have been synthesized with newly synthesized biologically active ligand. The novel ligand has been synthesized by the condensation of 2-amino-4-methyl-5-carbethoxy-1,3-thiazole and 8-formyl-7-hydroxy-4-methylcoumarin. The probable structure of the complexes has been proposed on the basis of analytical and spectroscopic data (IR, UV-Vis, ESR, ESI-mass and TG-DTA). Electro chemical study of the complexes has also been recorded. The elemental analyses of the complexes confine to the stoichiometry of the type ML2.2H2O [M=Co(II), Ni(II) and Cu(II)]. The Schiff base and its metal(II) complexes have been screened for their antibacterial (Staphylococcus aureus (MRSA), Escherichia coli, Salmonella typhi) and antifungal activity (Aspergillus niger, Candida albicans, Aspergillus flavus) by MIC method. The DNA cleavage is studied by agarose gel electrophoresis method.

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