Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
Abstract
The Underlying Mechanism of Action of the Antidiarrheal Activity of the Aqueous Extract of Salvia Verbenaca
Author(s): EL Akhal Mohammed*Ethnopharmacology relevance: Salvia verbenaca which belongs to the family of Lamiacaeae grows spontaneously in several regions in Morocco, where the dried leaves and flowers have a folkloric repute in the treatment of gastrointestinal symptoms, most commonly diarrhoea and dysentery and as diuretic agent. However, to the best of our knowledge, there is no scientific study justifying the traditional use of Salvia verbenaca in these conditions.
Aim of the study: The present study is designed to investigate scientifically and to provide pharmacological evidences on the antidiarrheal, property of the aqueous extract of Salvia verbenaca and to present data on its mechanisms of action effect on Wistar rats.
Materials and methods: The antidiarrheal activity of Aqueous Extract of Salvia verbenaca (AESV) was assessed using three models of acute diarrhea for efficacy assessment namely castor oil induced diarrhea, castor oil induced enteropooling and small intestinal transit in Albino wistar rats of either sex (150 g, 250 g).
Results: The aqueous extracts of Salvia verbenaca showed great antidiarrheal activity at the concentration of 50, 100 and 200 mg/kg body weight. Salvia verbenaca extracts reduced drastically the frequency and severity of diarrhea in test animals and markedly protected rats against castor oilinduced diarrheal enteropooling throughout the study period as compared to vehicle group. At the same doses (AESV) (p<0.001) dramatically delayed the intestinal transit of charcoal meal in test animals compared to the control.
Conclusions: The antidiarrheal property of the aqueous extract of Salvia verbenaca is described for the first time. Our findings proved that this plant extracts possess remarkable antidiarrheal. Overall, these results suggest that the Salvia verbenaca could be used as a potential antidiarrheal agent.
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